Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients

• Main Authors: Samar Samir Abdelmajed, Mohamed A. El-Dessouky, Doaa S. SalahElDin, Naglaa Abu-Mandil Hassan, Moushira Erfan Zaki, Somaia Ismail
• Format: Article
• Language: English
• Published: SpringerOpen 2021-08-01
• Series: Journal of Genetic Engineering and Biotechnology
• Subjects: Autoimmune disease; Diabetes type 1; Real-time PCR; rs7574865 polymorphism; Signal transducer and activator of transcription 4
• Online Access: https://doi.org/10.1186/s43141-021-00214-2

Abstract Background Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. Results A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. Conclusion It was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients.