Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma

Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma

Oncolytic Newcastle disease virus (NDV) might be a promising new therapeutic agent for the treatment of pancreatic cancer. We evaluated recombinant NDVs (rNDVs) expressing interferon (rNDV-hIFNβ-F\(_{\rm{0}}\)) or an IFN antagonistic protein (rNDV-NS1-F\(_{\rm{0}}\)), as well as rNDV with increased...

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Bibliographic Details
Main Authors: Pascal Buijs, Stefan van Nieuwkoop, Vincent Vaes, Ron Fouchier, Casper van Eijck, Bernadette van den Hoogen
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Viruses
Subjects:
oncolytic virus
oncolytic virotherapy
Newcastle disease virus
pancreatic adenocarcinoma
innate immunity
immunotherapy
Online Access:http://www.mdpi.com/1999-4915/7/6/2756

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http://www.mdpi.com/1999-4915/7/6/2756

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