Elevated Cerebrospinal fluid 5-hydroxyindoleacetic acid in Macaques Following Early Life Stress (ELS) and Inverse Association with Hippocampal Volume: Preliminary Implications for Serotonin-Related Function in Mood and Anxiety Disorders

Elevated Cerebrospinal fluid 5-hydroxyindoleacetic acid in Macaques Following Early Life Stress (ELS) and Inverse Association with Hippocampal Volume: Preliminary Implications for Serotonin-Related Function in Mood and Anxiety Disorders

Background: Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent monoamine metabolites. We sought to replicate an...

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Bibliographic Details
Main Authors: Jeremy D Coplan, Sasha L Fulton, Wade eReiner, Andrea eJackowski, Venkatesh ePanthangi, Tarique D Perera, Jack M Gorman, Yung-Yu eHuang, Cheuk Y Tang, Patrick R Hof, Arie eKaffman, Andrew eDwork, Sanjay J Mathew, Joan eKaufman, John J Mann
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
MRI
cisternal tap
serotonin metabolite
monoamine metabolites
VFD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00440/full

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