Endocannabinoids as Guardians of Metastasis

Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an ext...

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Main Author:	Irmgard Tegeder
Format:	Article
Language:	English
Published:	MDPI AG 2016-02-01
Series:	International Journal of Molecular Sciences
Subjects:	endocannabinoids anandamide 2-arachidonoylglycerol orphan G-protein coupled receptor immune cells angiogenesis
Online Access:	http://www.mdpi.com/1422-0067/17/2/230

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spelling	doaj-d45a4b5a5c52428f9ad2d4770f82680e2020-11-25T01:01:31ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-02-0117223010.3390/ijms17020230ijms17020230Endocannabinoids as Guardians of MetastasisIrmgard Tegeder0Institute of Clinical Pharmacology, University Hospital Frankfurt, GermanyEndocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis.http://www.mdpi.com/1422-0067/17/2/230endocannabinoidsanandamide2-arachidonoylglycerolorphan G-protein coupled receptorimmune cellsangiogenesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Irmgard Tegeder
spellingShingle	Irmgard Tegeder Endocannabinoids as Guardians of Metastasis International Journal of Molecular Sciences endocannabinoids anandamide 2-arachidonoylglycerol orphan G-protein coupled receptor immune cells angiogenesis
author_facet	Irmgard Tegeder
author_sort	Irmgard Tegeder
title	Endocannabinoids as Guardians of Metastasis
title_short	Endocannabinoids as Guardians of Metastasis
title_full	Endocannabinoids as Guardians of Metastasis
title_fullStr	Endocannabinoids as Guardians of Metastasis
title_full_unstemmed	Endocannabinoids as Guardians of Metastasis
title_sort	endocannabinoids as guardians of metastasis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2016-02-01
description	Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis.
topic	endocannabinoids anandamide 2-arachidonoylglycerol orphan G-protein coupled receptor immune cells angiogenesis
url	http://www.mdpi.com/1422-0067/17/2/230
work_keys_str_mv	AT irmgardtegeder endocannabinoidsasguardiansofmetastasis
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Endocannabinoids as Guardians of Metastasis

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