Sequence Features of Drosha and Dicer Cleavage Sites Affect the Complexity of IsomiRs

Sequence Features of Drosha and Dicer Cleavage Sites Affect the Complexity of IsomiRs

The deep-sequencing of small RNAs has revealed that different numbers and proportions of miRNA variants called isomiRs are formed from single miRNA genes and that this effect is attributable mainly to imprecise cleavage by Drosha and Dicer. Factors that influence the degree of cleavage precision of...

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Bibliographic Details
Main Authors: Julia Starega-Roslan, Tomasz M. Witkos, Paulina Galka-Marciniak, Wlodzimierz J. Krzyzosiak
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:International Journal of Molecular Sciences
Subjects:
miRNA precursor sequence
miRNA precursor structure
heterogeneity
homogeneity
Dicer
Drosha
Online Access:http://www.mdpi.com/1422-0067/16/4/8110

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