Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

Aims. To investigate the anticolorectal cancer (CRC) effects of Bufalin, a bioactive polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an established orthotopic xenograft model in mice, and to explore the mechanisms of action. Material and Methods. Cultured HCT116 cells or BAL...

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Bibliographic Details
Main Authors:	Jie Wang, Chao Chen, Shiying Wang, Yong Zhang, Peihao Yin, Zhongxiang Gao, Jie Xu, Dianxu Feng, Qinsong Zuo, Ronghua Zhao, Teng Chen
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Gastroenterology Research and Practice
Online Access:	http://dx.doi.org/10.1155/2015/457193

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