Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

Background: Voriconazole is a potent antifungal drug with complex pharmacokinetics caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also exhibits different pharmacokinetic characteristics between adults and children. An understanding of these alterations in pharmacok...

Full description

Bibliographic Details
Main Authors:	Yahui Zhang, Sixuan Zhao, Chuhui Wang, Pengxiang Zhou, Suodi Zhai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Pharmacology
Subjects:	voriconazole physiologically based pharmacokinetic model children gene dose optimization
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.636097/full

Similar Items

Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics of Voriconazole and Development of a Voriconazole Dosing Optimization Model in Thai Patients with Hematologic Diseases
by: Buddharat Khan-asa, et al.
Published: (2020-09-01)

Evaluation of Prophylactic Voriconazole and Posaconazole Concentration Monitoring and Dose Changes in Liquid and Solid Transplant Patients
by: Nguyen, Jill, et al.
Published: (2012)

Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats
by: Ji-Sang Lee, et al.
Published: (2021-05-01)

Pulmonary delivery of aqueous voriconazole solution
by: Tolman, Justin Andrew
Published: (2012)

Method for Therapeutic Drug Monitoring of Voriconazole and its Primary Metabolite Voriconazole-N-oxide in Human Serum using LC-MS/MS
by: Mendy ter Avest, et al.
Published: (2018-10-01)

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection
by: Zhi LJ, et al.
Published: (2018-04-01)

Extended or Continuous Infusion of Carbapenems in Children with Severe Infections: A Systematic Review and Narrative Synthesis
by: Pengxiang Zhou, et al.
Published: (2021-09-01)

Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags
by: Andréa I.H. Adams, et al.

Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review.
by: Hannah Yejin Kim, et al.
Published: (2020-06-01)

A Large Retrospective Assessment of Voriconazole Exposure in Patients Treated with Extracorporeal Membrane Oxygenation
by: Ruth Van Daele, et al.
Published: (2021-07-01)

Comparative study of prophylaxis with high and low doses of voriconazole in children with malignancy
by: Sviatlana Kandaurava, et al.
Published: (2020-12-01)

Model based characterization of pharmacokinetic interaction between voriconazole and cytarabine in patients with acute myeloid leukemia
by: Ματθιός, Ανδρέας
Published: (2014)

The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro
by: Xu RA, et al.
Published: (2018-11-01)

Uso de voriconazol en el período neonatal. Reporte de dos casos = Voriconazole use during the neonatal period. Report of two cases
by: Carvajal Kalil, Luis Fernando, et al.
Published: (2011-06-01)

Successful treatment of Chrysosporium keratitis with voriconazole
by: Thanathanee O, et al.
Published: (2017-03-01)

Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients
by: Miao Zhang, et al.
Published: (2021-02-01)

Interaction between voriconazole and glimepiride
by: Shobha J, et al.
Published: (2010-01-01)

A case of endogenous trichosporon endophthalmitis treated with micafungin and voriconazole
by: Harpreet Walia, et al.
Published: (2009-01-01)

Verapamil Inhibits Aspergillus Biofilm, but Antagonizes Voriconazole
by: Hasan Nazik, et al.
Published: (2017-09-01)

Voriconazole-induced periostitis
by: D.C. Fernández Ávila, et al.
Published: (2021-04-01)

Recurrent Acremonium infection in a kidney transplant patient treated with voriconazole: a case report Infecção recidivante por Acremonium em paciente transplantado renal tratado com voriconazol: relato de caso
by: Felipe Francisco Tuon, et al.
Published: (2010-08-01)

Voriconazole in Prevention and Treatment of Febrile Neutropenia
by: Hamidreza Taghva Masoumi, et al.
Published: (2018-02-01)

An appraisal of antifungal impacts of nano-liposome containing voriconazole on voriconazole-resistant Aspergillus flavus isolates as a groundbreaking drug delivery system
by: Parviz Hassanpour, et al.
Published: (2020-03-01)

Voriconazole-induced hypokalemia and hyponatremia and their correlations with voriconazole trough concentration
by: CHENG Lin, et al.
Published: (2020-07-01)

Cancer Immunotherapy Dosing: A Pharmacokinetic/Pharmacodynamic Perspective
by: Félicien Le Louedec, et al.
Published: (2020-10-01)

Hallucination in kidney transplant recipient: A rare complication of voriconazole
by: Manmeet Singh Jhawar, et al.
Published: (2017-01-01)

RP-HPTLC method for determination of Voriconazole in bulk and in cream formulation
by: Manali W. Jain, et al.
Published: (2017-02-01)

Meta-analysis of the safety of voriconazole in definitive, empirical, and prophylactic therapies for invasive fungal infections
by: Yuanming Xing, et al.
Published: (2017-12-01)

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers
by: Liu J, et al.
Published: (2020-02-01)

Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human
by: Fen Yang, et al.
Published: (2017-10-01)

Successful Treatment of Lasiodiplodia theobromae Keratitis – Assessing the Role of Voriconazole
by: Stephen Tak-lun Li, et al.
Published: (2016-10-01)

Natamycin versus voriconazole for fungal keratitis
by: José Retamal, et al.
Published: (2018-12-01)

Bronchoscopic Voriconazole Instillation in Pulmonary Aspergilloma: A Single Center Experience
by: Prajowl Shrestha, et al.
Published: (2019-06-01)

Comparison of Characteristics of Patients who Received Posaconazole or Voriconazole for the Treatment of Coccidioidomycosis
by: Hackman, Christine, et al.
Published: (2013)

Determination of voriconazole and its N-oxide in human plasma by LC-MS/MS and its clinical application
by: XIANG Rongfeng, et al.
Published: (2019-08-01)

Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis
by: Ha Eun Sim, et al.
Published: (2020-08-01)

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism
by: Ji Sang Lee, et al.
Published: (2019-07-01)

A physiologically-based pharmacokinetic model of oseltamivir phosphate and its carboxylate metabolite for rats and humans
by: Guanghua Gao, et al.
Published: (2019-02-01)

A case presentation of Voriconazole therapy in a brochopulmonary dysplasia
by: Elaheh Amini, et al.
Published: (2015-03-01)

A case presentation of Voriconazole therapy in a brochopulmonary dysplasia
by: Elaheh Amini, et al.
Published: (2015-03-01)