Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats

Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats

Genistein has a neuroprotective effect in Alzheimer's disease, but its mechanism of action needs further clarification. Accumulating evidence suggests that excessive phosphorylation of tau protein causes production of neurofibrillary tangles, which is one of the main pathological characteristic...

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Bibliographic Details
Main Authors: Shu Ye, Ting-ting Wang, Biao Cai, Yan Wang, Jing Li, Ji-xian Zhan, Guo-ming Shen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; neurodegeneration; genistein; Alzheimer′s disease; neuroprotection; hippocampus; learning; memory; tau protein; CAMK4; CALM; CAMKK1; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=9;spage=1479;epage=1484;aulast=Ye

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