Differential Regulation of mTOR Complexes with miR-302a Attenuates Myocardial Reperfusion Injury in Diabetes

Differential Regulation of mTOR Complexes with miR-302a Attenuates Myocardial Reperfusion Injury in Diabetes

Summary: Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We show here that infusion of rapamycin (mTOR inhibitor) at reperfusion following ischemia reduced myocardial infarct size and apoptosis w...

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Bibliographic Details
Main Authors: Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Human Metabolism
Molecular Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310609

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