The Safety and Efficacy of Tranexamic Acid in Oncology Patients Undergoing Endoprosthetic Reconstruction and a ROTEM-Based Evaluation of Their Hemostatic Profile: A Pilot Study

Background: An endoprosthetic reconstruction in musculoskeletal oncology patients is associated with significant blood loss. The purpose of this study is to evaluate the safety and efficacy of tranexamic acid (TXA) for these patients and to assess any changes in their hemostatic profile using rotati...

Full description

Bibliographic Details
Main Authors:	Andreas G. Tsantes, Ioannis G. Trikoupis, Dimitrios V. Papadopoulos, Stavros Goumenos, Daniele Piovani, Georgios K. Nikolopoulos, Argyri Gialeraki, Stefanos Bonovas, Panayiotis J. Papagelopoulos, Vasilios A. Kontogeorgakos, Argirios E. Tsantes
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Cancers
Subjects:	endoprosthetic reconstruction musculoskeletal oncology tranexamic acid rotational thromboelastometry blood loss hemostasis
Online Access:	https://www.mdpi.com/2072-6694/13/16/3951

Similar Items

Role of ROTEM in hemostatic management during adult cardiac surgery
by: Hooman Bakhshandeh, et al.
Published: (2016-01-01)

ENDOPROSTHETICS OF KNEE AND HIP JOINTS IN PATIENTS WITH RHEUMATIC DISEASES
by: V P Pavlov, et al.
Published: (2001-04-01)

THE RECOVERY THROUGH PHYSIOTHERAPY OF THE GERIATRIC PATIENTS SUFFERING FROM ENDOPROSTHETIC COXARTHROTHIS
by: Crăciun Airinei Alina – Elena, et al.
Published: (2018-11-01)

Biological agents for endoprosthetic joint replacement in patients with rheumatoid arthritis
by: Viktoria Nikolaevna Khlaboshina, et al.
Published: (2014-12-01)

Parameters of podobarography after hip total endoprosthetics at different surgical accesses
by: G. I. Herzen, et al.
Published: (2020-01-01)

Intraarticular use of tranexamic acid reduces blood loss and transfusion rate after primary total knee arthroplasty
by: Eric Tille, et al.
Published: (2019-07-01)

Endoprosthetic replacement in patients with tumors of proximal humerus
by: V. Yu. Karpenko, et al.
Published: (2015-06-01)

PRIMARY ENDOPROSTHETIC REPLACEMENT OF THE ANOPHTHALMIC ORBIT IN PATIENTS WITH UVEAL MELANOMA: SIX-YEAR FOLLOW-UP RESULTS
by: A. A. Yarovoy, et al.
Published: (2015-04-01)

Compressive osseointegration for endoprosthetic reconstruction
by: Lindsay Parlee, et al.
Published: (2020-11-01)

The access dependence of endoprosthetic ball dislocation in hip replacement
by: Abdulnasyrov R.K., et al.
Published: (2016-06-01)

Correlation of early ROTEM parameters with conventional coagulation tests in patients with chronic liver disease undergoing liver transplant
by: A Hashir, et al.
Published: (2019-01-01)

TEG<sup>®</sup> and ROTEM<sup>®</sup> Traces: Clinical Applications of Viscoelastic Coagulation Monitoring in Neonatal Intensive Care Unit
by: Giulia Cannata, et al.
Published: (2021-09-01)

Complications after endoprosthetic joint replacement in patients receiving genetically engineered biological agents
by: Elena Yuryevna Pogozheva, et al.
Published: (2012-06-01)

Survival and Ambulatory Function after Endoprosthetic Replacement for Metastatic Bone Tumor of the Proximal Femur
by: Nakashima, Hiroatsu, et al.
Published: (2010)

PERIPROSTHETIC INFECTION AFTER ENDOPROSTHETIC REPLACEMENT OF THE HIP JOINT IN PATIENTS WITH RHEUMATOID DISEASES
by: Vadim Petrovich Pavlov, et al.
Published: (2014-02-01)

SHOULD DISEASE-MODIFYING THERAPY BE STOPPED IN PATIENTS WITH RHEUMATOID ARTHRITIS BEFORE ENDOPROSTHETIC JOINT REPLACEMENT?
by: N. A. Savenkova, et al.
Published: (2011-06-01)

Development of the algorithm of differential hemostatic diagnostics based on thromboelastometry data
by: D. G. Ratskevich, et al.
Published: (2019-06-01)

Does endoprosthetic replacement of large joints improve quality of life in patients with rheumatoid arthritis?
by: Nadezhda Alekseevna Savenkova, et al.
Published: (2011-02-01)

The effect of a mixture of 2.7% sorbitol-0.54% mannitol solution on blood coagulation: an invitro, observational healthyvolunteer study using rotational thromboelastometry (ROTEM)
by: Hyun-Jung Shin, et al.
Published: (2019-04-01)

Study of the tribological properties of surface structures using ultrashort laser pulses to reduce wear in endoprosthetics
by: Lea Theresa Backes, et al.
Published: (2020-06-01)

Which factors are associated with the functional recovery in patients undergoing endoprosthetic knee reconstruction following bone tumour resection? – A observational study
by: Mattia Morri, et al.
Published: (2018-12-01)

Endoprosthetic Reconstruction of distal Humerus following Resection of distal Humeral Giant Cell Tumours in Six Patients in Rural India
by: Balasubramanian N, et al.
Published: (2017-07-01)

Managing anticoagulant patients undergoing dental extraction by using hemostatic agent: Tranexamic acid mouthrinse
by: Pragya Jaiswal, et al.
Published: (2021-01-01)

Clinical utility of rotational thromboelastometry in detecting hemostatic disorders
by: Sabljić Nikica, et al.
Published: (2020-01-01)

Trauma-induced coagulopathy. A narrative review of goal-directed hemostatic resuscitation
by: Federica Pigna, et al.
Published: (2018-12-01)

Altering the Course of Technologies to Monitor Loosening States of Endoprosthetic Implants
by: João Henrique Cachão, et al.
Published: (2019-12-01)

Compensation by nonoperated joints in the lower limbs during walking after endoprosthetic knee replacement following bone tumor resection
by: Okita, Yusuke
Published: (2014)

Hemostatic effect of tourniquet combined with tranexamic acid in total knee arthroplasty: a network meta-analysis
by: Yimin Zhang, et al.
Published: (2020-11-01)

The Procoagulant Effect of COVID-19 on the Thrombotic Risk of Patients with Hip Fractures Due to Enhanced Clot Strength and Fibrinolysis Shutdown
by: Andreas G. Tsantes, et al.
Published: (2021-07-01)

Viscoelastic Hemostatic Assays for Postpartum Hemorrhage
by: Alyson E. Liew-Spilger, et al.
Published: (2021-08-01)

Hemostatic and Histopathological Effects of Local Mineral Zeolite and Tranexamic Acid in Experimental Femoral Artery Bleeding Model
by: Altop Müzeyyen Seda, et al.
Published: (2021-07-01)

Tranexamic acid in melasma: a review
by: Amrit Kaur, et al.
Published: (2020-01-01)

THE USE OF TRANEXAMIC ACID IN RADICAL PROSTATECTOMY
by: Yancheuski P., et al.
Published: (2019-12-01)

Topical tranexamic acid for spontaneous epistaxis
by: María Jesús Santander, et al.
Published: (2018-12-01)

A randomised, open-label, comparative study of tranexamic acid microinjections and tranexamic acid with microneedling in patients with melasma
by: Leelavathy Budamakuntla, et al.
Published: (2013-01-01)

The Bateman-Type Soft Tissue Reconstruction around Proximal or Total Humeral Megaprostheses in Patients with Primary Malignant Bone Tumors—Functional Outcome and Endoprosthetic Complications
by: Helmut Ahrens, et al.
Published: (2021-08-01)

Intralesional tranexamic acid: Safe and effective way of treatment for melasma
by: Vani Veggalam, et al.
Published: (2017-01-01)

LOCAL APPLICATION OF TRANEXAMIC ACID IN KNEE REPLACEMENT
by: E. V. Pshenitsyna, et al.
Published: (2016-12-01)

Tranexamic acid in otorhinolaryngology – A contemporary review
by: Jordan Fuzi, et al.
Published: (2021-10-01)

Changes in the Hemostatic System in Threatened Abortion and Their Correction
by: Tarabrin O., et al.
Published: (2014-09-01)