Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro

Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro

Particulate matter with an aerodynamic diameter less than 2.5 μM (PM2.5) is one of the major environmental pollutants in China. In this study, we carried out a metabolomics profile study on PM2.5-induced inflammation. PM2.5 from Beijing, China, was collected and given to rats through intra-tracheal...

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Bibliographic Details
Main Authors: Song-Yang Zhang, Danqing Shao, Huiying Liu, Juan Feng, Baihuan Feng, Xiaoming Song, Qian Zhao, Ming Chu, Changtao Jiang, Wei Huang, Xian Wang
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
PM2.5
Benzo[a]pyrene
Pulmonary injury
Phospholipase A2
Alveolar type II cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717300137

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http://www.sciencedirect.com/science/article/pii/S2213231717300137

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