Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations

Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations

Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. To date, HEV infections can only be treated with ribavirin (RBV). Major drawbacks of this therapy are that RBV is not approved for administ...

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Bibliographic Details
Main Authors: Daniel Todt, Stephanie Walter, Richard J. P. Brown, Eike Steinmann
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Viruses
Subjects:
hepatitis E virus
ribavirin
RNA viruses
mutagenesis
intra-host population
Online Access:http://www.mdpi.com/1999-4915/8/10/283

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