Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection

Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection

Meningococcal meningitis is a severe central nervous system infection that occurs when Neisseria meningitidis (Nm) penetrates brain endothelial cells (BECs) of the meningeal blood-cerebrospinal fluid barrier. As a human-specific pathogen, in vivo models are greatly limited and pose a significant cha...

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Bibliographic Details
Main Authors: Sara F. Martins Gomes, Alexander J. Westermann, Till Sauerwein, Tobias Hertlein, Konrad U. Förstner, Knut Ohlsen, Marco Metzger, Eric V. Shusta, Brandon J. Kim, Antje Appelt-Menzel, Alexandra Schubert-Unkmeir
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
Neisseria meningitidis
meningococcus
bacteria
stem cells
blood-cerebrospinal fluid barrier
blood-brain barrier
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01181/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01181/full

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