Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques

Lassa virus is one of the most common causes of viral hemorrhagic fever. A frequent, but as yet unexplained, consequence of infection with Lassa virus is acute, sudden-onset sensorineural hearing loss in one or both ears. Deafness is observed in approximately 30% of surviving Lassa fever patients, a...

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Bibliographic Details
Main Authors: Kathleen A. Cashman, Eric R. Wilkinson, Xiankun Zeng, Anthony P. Cardile, Paul R. Facemire, Todd M. Bell, Jeremy J. Bearss, Carl I. Shaia, Connie S. Schmaljohn
Format: Article
Language:English
Published: American Society for Microbiology 2018-10-01
Series:mBio
Subjects:
Lassa virus
Lassa fever
polyarteritis nodosa
microscopic polyangiitis
vasculitides
autoimmunity
viral infection
viral hemorrhagic fever
cynomolgus macaque
nonhuman primate
deafness
sensorineural hearing loss
brainstem auditory evoked response
virus-associated deafness
anti-neutrophilic cytoplasmic antibodies
ANCA
ANCA-associated vasculitis
autoimmune-associated vasculitis
immune-mediated vasculitis
Online Access:https://doi.org/10.1128/mBio.01896-18

Internet

https://doi.org/10.1128/mBio.01896-18

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