Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux

Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux

Abstract Background Gliomas are the most common primary tumors in central nervous system. Despite advances in diagnosis and therapy, the prognosis of glioma remains gloomy. Autophagy is a cellular catabolic process that degrades proteins and damaged organelles, which is implicated in tumorigenesis a...

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Bibliographic Details
Main Authors:	Zhi-peng Wen, Wen-jing Zeng, Yan-hong Chen, He Li, Jie-ya Wang, Quan Cheng, Jing Yu, Hong-hao Zhou, Zheng-zheng Liu, Jian Xiao, Xiao-ping Chen
Format:	Article
Language:	English
Published:	BMC 2019-07-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	Glioma Glioblastoma ATG4C Autophagy Temozolomide
Online Access:	http://link.springer.com/article/10.1186/s13046-019-1287-8

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