Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8

Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8

PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation. Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by interacting with PUF binding element (PBE) in the 3′ untranslated region (3′ UTR). In this work, an in silico analysis has identified gld-2 [...

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Bibliographic Details
Main Authors: Youngyong Park, Samuel O’Rourke, Faten A. Taki, Mohammad A. Alfhili, Myon Hee Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PUF-8
GLD-2
C. elegans
differentiation
dedifferentiation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00005/full

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