Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
<p>Abstract</p> <p>Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25<sup>high </sup>regulatory T cells are the best-described subset. In this article, we summarize current knowledg...
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| Format: | Article |
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BMC
2008-12-01
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| Series: | Pediatric Rheumatology Online Journal |
| Online Access: | http://www.ped-rheum.com/content/6/1/20 |
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doaj-d3d1398d2cb34686b472d292015300aa2020-11-24T22:00:42ZengBMCPediatric Rheumatology Online Journal1546-00962008-12-01612010.1186/1546-0096-6-20Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic developmentWara DianeNguyen Khoa DMilojevic DianaMellins Elizabeth D<p>Abstract</p> <p>Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25<sup>high </sup>regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25<sup>high </sup>regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.</p> http://www.ped-rheum.com/content/6/1/20 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wara Diane Nguyen Khoa D Milojevic Diana Mellins Elizabeth D |
| spellingShingle |
Wara Diane Nguyen Khoa D Milojevic Diana Mellins Elizabeth D Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development Pediatric Rheumatology Online Journal |
| author_facet |
Wara Diane Nguyen Khoa D Milojevic Diana Mellins Elizabeth D |
| author_sort |
Wara Diane |
| title |
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development |
| title_short |
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development |
| title_full |
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development |
| title_fullStr |
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development |
| title_full_unstemmed |
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development |
| title_sort |
regulatory t cells and their role in rheumatic diseases: a potential target for novel therapeutic development |
| publisher |
BMC |
| series |
Pediatric Rheumatology Online Journal |
| issn |
1546-0096 |
| publishDate |
2008-12-01 |
| description |
<p>Abstract</p> <p>Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25<sup>high </sup>regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25<sup>high </sup>regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.</p> |
| url |
http://www.ped-rheum.com/content/6/1/20 |
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