Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
<p>Abstract</p> <p>Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25<sup>high </sup>regulatory T cells are the best-described subset. In this article, we summarize current knowledg...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-12-01
|
| Series: | Pediatric Rheumatology Online Journal |
| Online Access: | http://www.ped-rheum.com/content/6/1/20 |
| Summary: | <p>Abstract</p> <p>Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25<sup>high </sup>regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25<sup>high </sup>regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.</p> |
|---|---|
| ISSN: | 1546-0096 |