PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway

PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway

A growing amount of evidence has confirmed the crucial role of the prolyl isomerase PIN1 in aging and age-related diseases. However, the mechanism of PIN1 in age-related hearing loss (ARHL) remains unclear. Pathologically, ARHL is primarily due to the loss and dysfunction of hair cells (HCs) and spi...

Full description

Bibliographic Details
Main Authors:	Yanzhuo Zhang, Zhe Lv, Yudong Liu, Huan Cao, Jianwang Yang, Baoshan Wang
Format:	Article
Language:	English
Published:	Hindawi Limited 2021-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2021/9980444

Similar Items

Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin Ototoxicity
by: Zhiwei Zheng, et al.
Published: (2020-01-01)

Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells
by: Song Gao, et al.
Published: (2020-02-01)

Differentiation of embryonic stem cells into a putative hair cell-progenitor cells via co-culture with HEI-OC1 cells
by: Nathaniel T. Carpena, et al.
Published: (2021-07-01)

Interleukin-10 Attenuates Hypochlorous Acid-Mediated Cytotoxicity to HEI-OC1 Cochlear Cells
by: Martin Mwangi, et al.
Published: (2017-10-01)

Akt and mTOR in B cell activation and differentiation
by: David A. Fruman, et al.
Published: (2012-08-01)

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
by: Angel Cayo, et al.
Published: (2021-07-01)

Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells
by: Ann-Ki Pålbrink, et al.
Published: (2020-04-01)

The effect of AP-2δ on transcription of the Prestin gene in HEI-OC1 cells upon oxidative stress
by: Xuan Luo, et al.
Published: (2019-06-01)

The paradox of Akt -mTOR interactions
by: LAKSHMIPATHI eVADLAKONDA, et al.
Published: (2013-06-01)

Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage
by: He Li, et al.
Published: (2018-05-01)

EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling
by: Dong-dong Cheng, et al.
Published: (2018-03-01)

Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress
by: Liu Zhibiao, et al.
Published: (2021-07-01)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
by: Kerstin Tiedemann, et al.
Published: (2017-05-01)

The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation.
by: Ramesh Yentrapalli, et al.
Published: (2013-01-01)

Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling
by: Hyunsook Kang, et al.
Published: (2020-01-01)

Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis
by: Yu Cui, et al.
Published: (2016-04-01)

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells.
by: Eliane Antonioli, et al.
Published: (2019-01-01)

Akt1 enhances CA916798 expression through mTOR pathway.
by: Yu-Liang Wang, et al.
Published: (2013-01-01)

SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
by: Xu H, et al.
Published: (2018-07-01)

Essential Roles of mTOR/Akt Pathway in Aurora-A Cell Transformation
by: Makoto Taga, Eiji Hirooka, Toru Ouchi
Published: (2009-01-01)

GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling
by: Fan Zhang, et al.
Published: (2021-01-01)

RRS1 Promotes Retinoblastoma Cell Proliferation and Invasion via Activating the AKT/mTOR Signaling Pathway
by: Xuejing Yan, et al.
Published: (2020-01-01)

Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway
by: Shangfeng Gao, et al.
Published: (2017-06-01)

Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas.
by: Jean-Michel Maury, et al.
Published: (2019-01-01)

Synergistic Effects of Combination Therapy with AKT and mTOR Inhibitors on Bladder Cancer Cells
by: Hyera Kim, et al.
Published: (2020-04-01)

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
by: Grabinski Nicole, et al.
Published: (2012-11-01)

ROLE OF PI3K-AKT-mTOR AND Wnt SIGNALING PATHWAYS IN G1-S TRANSITION OF CELL CYCLE IN CANCER CELLS
by: LAKSHMIPATHI eVADLAKONDA, et al.
Published: (2013-04-01)

NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling
by: Feilin Liu, et al.
Published: (2019-01-01)

Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
by: Mounir El Maï, et al.
Published: (2020-05-01)

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence
by: Elwira Strozyk, et al.
Published: (2013-07-01)

Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway
by: Ling Li, et al.
Published: (2019-02-01)

Combination Effect of Notch1 and PI3K / AKT / mTOR Signaling Pathways Inhibitors on T-ALL Cell Lines
by: Halimeh Khoshamooz, et al.
Published: (2020-04-01)

Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway
by: Qian Meng BD, et al.
Published: (2020-03-01)

<i>FMR1</i> and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response
by: Julia Rehnitz, et al.
Published: (2021-08-01)

TCP1 regulates PI3K/AKT/mTOR signaling pathway to promote proliferation of ovarian cancer cells
by: Huixi Weng, et al.
Published: (2021-06-01)

PI3K/AKT/mTOR pathway in Angiogenesis
by: Jayashree eKarar, et al.
Published: (2011-12-01)

Sulforaphane regulates AKT/mTOR/S6K pathway in human breast cancer cells
by: Chiao-Ying Lien, et al.
Published: (2014)

TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt‐mTOR pathway
by: Hongxia Huang, et al.
Published: (2020-08-01)

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells
by: Ghosh Sadashib, et al.
Published: (2010-06-01)

Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
by: Hong Qiao, et al.
Published: (2018-06-01)

Cannot write session to /tmp/vufind_sessions/sess_oqcv38rvl3l79f17jgbireah4e