<i>TPMT*3C</i> as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia

<i>TPMT*3C</i> as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia

The response to 6-mercaptopurine (6-MP) can be altered by genetic polymorphisms in genes encoding drug-metabolizing enzymes and drug transporters. The purpose of this study was to investigate the association between genetic polymorphisms of drug-metabolizing enzymes (<i>TPMT 719A</i> >...

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Bibliographic Details
Main Authors: Thawinee Jantararoungtong, Supaporn Wiwattanakul, Rawiporn Tiyasirichokchai, Santirhat Prommas, Rattanaporn Sukprasong, Napatrupron Koomdee, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Samart Pakakasama, Usanarat Anurathapan, Suradej Hongeng, Chonlaphat Sukasem
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Journal of Personalized Medicine
Subjects:
<i>TPMT</i> genotype
6-mercaptopurine
myelotoxicity
acute lymphoblastic leukemia
Online Access:https://www.mdpi.com/2075-4426/11/8/783

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