A Combinatorial Approach to Biophysically Characterise Chemokine-Glycan Binding Affinities for Drug Development

A Combinatorial Approach to Biophysically Characterise Chemokine-Glycan Binding Affinities for Drug Development

Chemokine binding to glycosaminoglycans (GAGs) is recognised to be an important step in inflammation and other pathological disorders like tumor growth and metastasis. Although different ways and strategies to interfere with these interactions are being pursued, no major breakthrough in the developm...

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Bibliographic Details
Main Authors: Tanja Gerlza, Bianca Hecher, Dalibor Jeremic, Thomas Fuchs, Martha Gschwandtner, Angelika Falsone, Bernd Gesslbauer, Andreas J. Kungl
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
chemokines
fluorescence spectroscopy
glycosaminoglycans
heparan sulfate
surface plasmon resonance
Online Access:http://www.mdpi.com/1420-3049/19/7/10618

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