Transbilayer phospholipid movements in ABCA1-deficient cells.

Tangier disease is an inherited disorder that results in a deficiency in circulating levels of HDL. Although the disease is known to be caused by mutations in the ABCA1 gene, the mechanism by which lesions in the ABCA1 ATPase effect this outcome is not known. The inability of ABCA1 knockout mice (AB...

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Bibliographic Details
Main Authors: Patrick Williamson, Margaret S Halleck, Jonathan Malowitz, Susan Ng, Xiaoxuan Fan, Stephen Krahling, Alan T Remaley, Robert A Schlegel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1939730?pdf=render