MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner

MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner

PURPOSE: Increased murine double minute 2 (MDM2) expression, independent of p53 status, is associated with increased cancer-specific mortality for men with prostate cancer treated with radiotherapy. We assessed MI-219, a small molecule inhibitor of MDM2 with improved pharmacokinetics over nutlin-3,...

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Bibliographic Details
Main Authors: Felix Y. Feng, Yu Zhang, Vishal Kothari, Joseph R. Evans, William C. Jackson, Wei Chen, Skyler B. Johnson, Connor Luczak, Shaomeng Wang, Daniel A. Hamstra
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616000166

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