Knockout of p53 leads to a significant increase in ALV-J replication

Knockout of p53 leads to a significant increase in ALV-J replication

ABSTRACT: Avian leukemia is a common malignant disease, and and its regulatory mechanism is complex. As the most extensive tumor suppressor gene in cancer research, p53 can control multiple functions such as that of DNA repair, induction of apoptosis, cell cycle arrest and so on. In view of the dive...

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Bibliographic Details
Main Authors: Hui Zhang, Huixia Zhang, Shengliang Cao, Chao Sui, Yinuo Song, Yiran Zhao, Sidang Liu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Poultry Science
Subjects:
ALV-J
p53
CRISPR-Cas9
cytokines
cell cycle and apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0032579121003977

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