Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans

Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans

Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features...

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Main Authors: Mu Yuan, Ming-Zhu Bai, Xu-Feng Huang, Yue Zhang, Jing Liu, Min-Hao Hu, Wei-Qian Zheng, Fan Jin
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/184845
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spelling doaj-d3b07dbc0c8341f4bfbfe6e6dec1ae9c2020-11-24T22:17:51ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/184845184845Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in HumansMu Yuan0Ming-Zhu Bai1Xu-Feng Huang2Yue Zhang3Jing Liu4Min-Hao Hu5Wei-Qian Zheng6Fan Jin7Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, ChinaDepartment of Obstetrics and Gynecology, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai 201600, ChinaSchool of Medicine, University of Wollongong and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, AustraliaDepartment of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, ChinaEndocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.http://dx.doi.org/10.1155/2015/184845
collection DOAJ
language English
format Article
sources DOAJ
author Mu Yuan
Ming-Zhu Bai
Xu-Feng Huang
Yue Zhang
Jing Liu
Min-Hao Hu
Wei-Qian Zheng
Fan Jin
spellingShingle Mu Yuan
Ming-Zhu Bai
Xu-Feng Huang
Yue Zhang
Jing Liu
Min-Hao Hu
Wei-Qian Zheng
Fan Jin
Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
BioMed Research International
author_facet Mu Yuan
Ming-Zhu Bai
Xu-Feng Huang
Yue Zhang
Jing Liu
Min-Hao Hu
Wei-Qian Zheng
Fan Jin
author_sort Mu Yuan
title Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
title_short Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
title_full Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
title_fullStr Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
title_full_unstemmed Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
title_sort preimplantation exposure to bisphenol a and triclosan may lead to implantation failure in humans
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.
url http://dx.doi.org/10.1155/2015/184845
work_keys_str_mv AT muyuan preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT mingzhubai preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT xufenghuang preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT yuezhang preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT jingliu preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT minhaohu preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT weiqianzheng preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
AT fanjin preimplantationexposuretobisphenolaandtriclosanmayleadtoimplantationfailureinhumans
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