Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone

Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone

Abstract: Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic ag...

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Bibliographic Details
Main Authors: Joshua D. Bernstock, Craig S. Budinich, Leonardo G Cohen, Oluwole O. Awosika
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Neurology
Subjects:
Pain Management
Stroke
plasticity
Opioids
Recrudescence of symptoms
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00050/full
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spelling doaj-d3af57626bf24c5899986747ed69eb612020-11-24T23:00:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952016-03-01710.3389/fneur.2016.00050187816Recrudescence of Focal Stroke Symptoms During Pain Management with HydromorphoneJoshua D. Bernstock0Craig S. Budinich1Leonardo G Cohen2Oluwole O. Awosika3National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH)Dwight D. Eisenhower Army Medical CenterNational Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH)National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH)Abstract: Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s), and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity.http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00050/fullPain ManagementStrokeplasticityOpioidsRecrudescence of symptoms
collection DOAJ
language English
format Article
sources DOAJ
author Joshua D. Bernstock
Craig S. Budinich
Leonardo G Cohen
Oluwole O. Awosika
spellingShingle Joshua D. Bernstock
Craig S. Budinich
Leonardo G Cohen
Oluwole O. Awosika
Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone
Frontiers in Neurology
Pain Management
Stroke
plasticity
Opioids
Recrudescence of symptoms
author_facet Joshua D. Bernstock
Craig S. Budinich
Leonardo G Cohen
Oluwole O. Awosika
author_sort Joshua D. Bernstock
title Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone
title_short Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone
title_full Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone
title_fullStr Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone
title_full_unstemmed Recrudescence of Focal Stroke Symptoms During Pain Management with Hydromorphone
title_sort recrudescence of focal stroke symptoms during pain management with hydromorphone
publisher Frontiers Media S.A.
series Frontiers in Neurology
issn 1664-2295
publishDate 2016-03-01
description Abstract: Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s), and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity.
topic Pain Management
Stroke
plasticity
Opioids
Recrudescence of symptoms
url http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00050/full
work_keys_str_mv AT joshuadbernstock recrudescenceoffocalstrokesymptomsduringpainmanagementwithhydromorphone
AT craigsbudinich recrudescenceoffocalstrokesymptomsduringpainmanagementwithhydromorphone
AT leonardogcohen recrudescenceoffocalstrokesymptomsduringpainmanagementwithhydromorphone
AT oluwoleoawosika recrudescenceoffocalstrokesymptomsduringpainmanagementwithhydromorphone
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