PhenoMapping: A protocol to map cellular phenotypes to metabolic bottlenecks, identify conditional essentiality, and curate metabolic models
Summary: Targeted identification of cellular processes responsible for a phenotype is of major importance in guiding efforts in bioengineering and medicine. Genome-scale metabolic models (GEMs) are widely used to integrate various types of omics data and study the cellular physiology under different...
Main Authors: | Anush Chiappino-Pepe, Vassily Hatzimanikatis |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
|
Series: | STAR Protocols |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666166720302677 |
Similar Items
-
Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.
by: Anush Chiappino-Pepe, et al.
Published: (2017-03-01) -
NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
by: Homa MohammadiPeyhani, et al.
Published: (2021-08-01) -
PhenoTimer: software for the visual mapping of time-resolved phenotypic landscapes.
by: Maria Secrier, et al.
Published: (2013-01-01) -
Statistical inference in ensemble modeling of cellular metabolism.
by: Tuure Hameri, et al.
Published: (2019-12-01) -
Analysis and design of metabolic reaction networks
by: Hatzimanikatis, Vassily
Published: (1997)