Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System

Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System

Azathioprine (AZA) is widely used in clinical practice for preventing graft rejection in organ transplantations and various autoimmune and dermatological diseases with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of AZA towards isolated rat hepatocytes were i...

Full description

Bibliographic Details
Main Authors:	Abdullah Al Maruf, Luke Wan, Peter J. O’Brien
Format:	Article
Language:	English
Published:	Hindawi Limited 2014-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2014/379748

Similar Items

Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System
by: Abdullah Al Maruf, et al.
Published: (2014-01-01)

Long-Term Treatment of Azathioprine in Rats Induces Vessel Mineralization
by: Mirjam Schuchardt, et al.
Published: (2021-03-01)

Azathioprine Hypersensitivity Syndrome: Two Cases of Febrile Neutrophilic Dermatosis Induced by Azathioprine
by: Majed Aleissa, et al.
Published: (2017-01-01)

Cytotoxicity of hexavalent chromium in rat hepatocytes
by: Gunaratnam, Mekala
Published: (2003)

Evaluating the Effect of Ginger Extract on Azathioprine-Induced Renal Failure in Mature Female Rats
by: Zahra Godarzian, et al.
Published: (2018-07-01)

Isolated Hepatocytes versus Hepatocyte Spheroids: In Vitro Culture of Rat Hepatocytes
by: Giovanni Ambrosino M.D., et al.
Published: (2005-07-01)

Azathioprine-Induced Severe Bone Marrow Suppression
by: Marzie Ghalamkari, et al.
Published: (2019-07-01)

Azathioprine induced pancytopenia: A serious complication
by: Hadda V, et al.
Published: (2009-01-01)

Effectiveness of Echinacea purpurea extract on immune deficiency induced by azathioprine in male albino rats
by: Emad Mohamed El-Sherbiny, et al.
Published: (2021-06-01)

Azathioprine for atopic eczema
by: Meggitt, Simon
Published: (2006)

Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments
by: James K. Morelli, et al.
Published: (2013-01-01)

Azathioprine-Induced Pericarditis in a Patient with Ulcerative Colitis
by: C David Simpson
Published: (1997-01-01)

Thalidomide Combined With Azathioprine as Induction and Maintenance Therapy for Azathioprine-Refractory Crohn's Disease Patients
by: Tong Li, et al.
Published: (2020-11-01)

Photodegration of azathioprine and related compounds
by: McLelland, M. A.
Published: (1988)

Cytochrome P450-mediated metabolism and cytotoxicity in rat cultured hepatocytes
by: Hammond, Alison H.
Published: (1990)

Resveratrol Inhibited Hydroquinone-Induced Cytotoxicity in Mouse Primary Hepatocytes
by: Noriyoshi Masuoka, et al.
Published: (2012-09-01)

Venlafaxine-Induced Cytotoxicity Towards Isolated Rat Hepatocytes Involves Oxidative Stress and Mitochondrial/Lysosomal Dysfunction
by: Elham Ahmadian, et al.
Published: (2016-12-01)

Azathioprine-induced alopecia as an early clinical marker of its myelotoxicity
by: Anil B Bhokare
Published: (2017-01-01)

Corticosteroids and Azathioprine Do Not Prevent Radiation-Induced Lung Injury
by: Eva Kwok, et al.
Published: (1998-01-01)

Accelerated Cytotoxicity Mechanism Screening of 4-Aminobiphenyl in an in vitro Hepatocyte Inflammation Model
by: Delaney, Sarah
Published: (2011)

Accelerated Cytotoxicity Mechanism Screening of 4-Aminobiphenyl in an in vitro Hepatocyte Inflammation Model
by: Delaney, Sarah
Published: (2011)

In vitro Liver Zonation of Primary Rat Hepatocytes
by: Lauren Tomlinson, et al.
Published: (2019-02-01)

Azathioprine Hypersensitivity Syndrome in an Asian Woman
by: Li-En Tao, et al.
Published: (2020-06-01)

Posterior Reversible Encephalopathy Syndrome and Azathioprine
by: Sara Pinto Teixeira Vilas-Boas, et al.
Published: (2019-01-01)

Azathioprine favourably influences the course of malaria
by: Huber Stephan M, et al.
Published: (2009-05-01)

Treatment of Sclerosing Mesenteritis with Corticosteroids and Azathioprine
by: Anand Bala, et al.
Published: (2001-01-01)

Azathioprin bei chronisch entzündlichen Darmerkrankungen
by: Daczo, Jürgen
Published: (2007)

Azathioprine use in inflammatory bowel disease
by: Campbell, Simon Scott
Published: (2003)

Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient
by: Joana Inês Alves da Silva, et al.
Published: (2020-01-01)

A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia
by: Yong Sung Choi, et al.
Published: (2011-07-01)

Protective effect of pumpkin seed oil against genotoxicity induced by azathioprine
by: S.A. Elfiky, et al.
Published: (2012-10-01)

Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma
by: Hye Jin Nam, et al.
Published: (2021-03-01)

Effects of the Amino Acid Constituents of Microcystin Variants on Cytotoxicity to Primary Cultured Rat Hepatocytes
by: Kumiko Shimizu, et al.
Published: (2013-12-01)

Protective Effects of N-acetylcysteine Against the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes
by: Narges Abdoli, et al.
Published: (2014-05-01)

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes
by: Nhareet Somchit, et al.
Published: (2009-01-01)

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes
by: Ahmad, Z, et al.

Redox Mechanism of Azathioprine and Its Interaction with DNA
by: Mihaela-Cristina Bunea, et al.
Published: (2021-06-01)

What are the effects of adding azathioprine to corticosteroids in polymyositis?
by: Cristina Meneses, et al.
Published: (2015-07-01)

Prolonged remission of psoriasis with azathioprine pulse therapy
by: Ramji Gupta
Published: (2015-01-01)

Drug Hypersensitivity due to Azathioprine with Elevated Procalcitonin
by: Tania Ahuja, et al.
Published: (2018-01-01)