Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing

The transcription factor Nkx2.5 is essential for heart development. Here, the authors identify a previously unknown expression domain for Nkx2.5 in the emu wing and explore its role in diminished wing bud development in the flightless emu, compared with three other birds that have functional wings.

Bibliographic Details
Main Authors:	Peter G. Farlie, Nadia M. Davidson, Naomi L. Baker, Mai Raabus, Kelly N. Roeszler, Claire Hirst, Andrew Major, Mylene M. Mariette, David M. Lambert, Alicia Oshlack, Craig A. Smith
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00112-7

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spelling	doaj-d39fc2c1c3a943f48666365a2d6c0c282021-01-31T12:31:53ZengNature Publishing GroupNature Communications2041-17232017-07-018111210.1038/s41467-017-00112-7Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wingPeter G. Farlie0Nadia M. Davidson1Naomi L. Baker2Mai Raabus3Kelly N. Roeszler4Claire Hirst5Andrew Major6Mylene M. Mariette7David M. Lambert8Alicia Oshlack9Craig A. Smith10Murdoch Children’s Research Institute, Royal Children’s HospitalMurdoch Children’s Research Institute, Royal Children’s HospitalMurdoch Children’s Research Institute, Royal Children’s HospitalMurdoch Children’s Research Institute, Royal Children’s HospitalMurdoch Children’s Research Institute, Royal Children’s HospitalBiomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash UniversityBiomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash UniversityCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin UniversityEnvironmental Futures Research Institute, Griffith UniversityMurdoch Children’s Research Institute, Royal Children’s HospitalMurdoch Children’s Research Institute, Royal Children’s HospitalThe transcription factor Nkx2.5 is essential for heart development. Here, the authors identify a previously unknown expression domain for Nkx2.5 in the emu wing and explore its role in diminished wing bud development in the flightless emu, compared with three other birds that have functional wings.https://doi.org/10.1038/s41467-017-00112-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peter G. Farlie Nadia M. Davidson Naomi L. Baker Mai Raabus Kelly N. Roeszler Claire Hirst Andrew Major Mylene M. Mariette David M. Lambert Alicia Oshlack Craig A. Smith
spellingShingle	Peter G. Farlie Nadia M. Davidson Naomi L. Baker Mai Raabus Kelly N. Roeszler Claire Hirst Andrew Major Mylene M. Mariette David M. Lambert Alicia Oshlack Craig A. Smith Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing Nature Communications
author_facet	Peter G. Farlie Nadia M. Davidson Naomi L. Baker Mai Raabus Kelly N. Roeszler Claire Hirst Andrew Major Mylene M. Mariette David M. Lambert Alicia Oshlack Craig A. Smith
author_sort	Peter G. Farlie
title	Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
title_short	Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
title_full	Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
title_fullStr	Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
title_full_unstemmed	Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
title_sort	co-option of the cardiac transcription factor nkx2.5 during development of the emu wing
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-07-01
description	The transcription factor Nkx2.5 is essential for heart development. Here, the authors identify a previously unknown expression domain for Nkx2.5 in the emu wing and explore its role in diminished wing bud development in the flightless emu, compared with three other birds that have functional wings.
url	https://doi.org/10.1038/s41467-017-00112-7
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Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing

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