The expression of cytochrome P4502J2 gene and 14, 15 epoxyeicosatrienoic acid level influence the amount of insulin secreted from human mesenchymal stem cell-derived insulin-producing cells

The expression of cytochrome P4502J2 gene and 14, 15 epoxyeicosatrienoic acid level influence the amount of insulin secreted from human mesenchymal stem cell-derived insulin-producing cells

Abstract Background Insulin-producing cells differentiated from human mesenchymal stem cells demonstrate limited glucose-stimulated insulin secretion. Cytochrome P450 2J2 and its product epoxyeicosatrienoic acids regulate β-cell function in the human pancreas. The aim of this study is to explore the...

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Bibliographic Details
Main Authors: Loaa A. Tag Eldeen, Marow El Sheikh, Salwa Faisal
Format: Article
Language:English
Published: SpringerOpen 2018-10-01
Series:Bulletin of the National Research Centre
Subjects:
Insulin-producing cells
Cytochrome P4502J2
14, 15 Epoxyeicosatrienoic acid
Pancreatic duodenal homeobox-1 mRNA
Insulin mRNA
Human mesenchymal stem cells
Online Access:http://link.springer.com/article/10.1186/s42269-018-0015-4

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http://link.springer.com/article/10.1186/s42269-018-0015-4

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