Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1)

• Main Authors: Abd-El Hamid Mahmoud M, Abou Dawood Abdel Gawad I, Sitohy Mahmoud Z, Mehrez Mona A, Taha Soad H, Kilany Walid H
• Format: Article
• Language: English
• Published: BMC 2010-11-01
• Series: Virology Journal
• Online Access: http://www.virologyj.com/content/7/1/330

<p>Abstract</p> <p>Background</p> <p>Avian influenza A (H5N1) virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions (α- lactalbumin, β- lactoglobulin, and lactoferrin) was evaluated against A/chicken/Egypt/086Q-NLQP/2008 HPAI (H5N1) strain of clade 2.2.1 (for multiplicity of infection (1 MOI) after 72 h of incubation at 37°C in the presence of 5% CO₂) using MDCK cell lines.</p> <p>Result</p> <p>Both the native and esterified lactoferrin seem to be the most active antiviral protein among the tested samples, followed by β- lactoglobulin. α-Lactalbumin had less antiviral activity even after esterification.</p> <p>Conclusion</p> <p>Esterification of whey proteins fractions especially lactoferrin and β-lactoglobulin enhanced their antiviral activity against H5N1 in a concentration dependent manner.</p>