In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
Abstract Moderate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propos...
Main Authors: | Yeong Lan Tan, Min En Nga, Han Kiat Ho |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-09-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-98078-6 |
Similar Items
-
Hypothermia Advocates Functional Mitochondria and Alleviates Oxidative Stress to Combat Acetaminophen-Induced Hepatotoxicity
by: Yeong Lan Tan, et al.
Published: (2020-10-01) -
Moderate Hypothermia Effectively Alleviates Acetaminophen-Induced Liver Injury With Prolonged Action Beyond Cooling
by: Yeong Lan Tan, et al.
Published: (2020-11-01) -
Hepatotoxic potential of asarones: In vitro evaluation of hepatotoxicity and quantitative determination in herbal products
by: Dhavalkumar Narendrabha Patel, et al.
Published: (2015-02-01) -
The ameliorating effects of Vitamin E on hepatotoxicity of ecstasy
by: Masoumeh Zirak Javanmard, et al.
Published: (2020-01-01) -
Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
by: Jie Kai Tee, et al.
Published: (2018-09-01)