3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione
The indole ring system is a prominent partial structure of several protein kinase inhibitor families. The title compound is the first example of a 5-substituted indolyl squaryl chloride with free indole nitrogen. It has been synthesized by reaction of 5-methoxyindole with squaric acid dichloride in...
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MDPI AG
2013-07-01
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| Series: | Molbank |
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| Online Access: | http://www.mdpi.com/1422-8599/2013/3/M805 |
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doaj-d372471292bc4a48a6dc4bda73d845082020-11-24T21:06:57ZengMDPI AGMolbank1422-85992013-07-0120133M80510.3390/M8053-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dioneJohann GrünefeldJana SchoemakerConstanze RurkaCaren RengerVincent ReimannMarleen MessalDuc Hoàng LandeNadin K. SchröderThe indole ring system is a prominent partial structure of several protein kinase inhibitor families. The title compound is the first example of a 5-substituted indolyl squaryl chloride with free indole nitrogen. It has been synthesized by reaction of 5-methoxyindole with squaric acid dichloride in diethyl ether and its IR, 1H-NMR, 13C-NMR, MS, UV and HPLC data are presented. This compound may prove to be a rather useful building block for the preparation of various derivatives for biological studies.http://www.mdpi.com/1422-8599/2013/3/M805Friedel-Crafts acylationindolesquaric acid dichloride |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Johann Grünefeld Jana Schoemaker Constanze Rurka Caren Renger Vincent Reimann Marleen Messal Duc Hoàng Lande Nadin K. Schröder |
| spellingShingle |
Johann Grünefeld Jana Schoemaker Constanze Rurka Caren Renger Vincent Reimann Marleen Messal Duc Hoàng Lande Nadin K. Schröder 3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione Molbank Friedel-Crafts acylation indole squaric acid dichloride |
| author_facet |
Johann Grünefeld Jana Schoemaker Constanze Rurka Caren Renger Vincent Reimann Marleen Messal Duc Hoàng Lande Nadin K. Schröder |
| author_sort |
Johann Grünefeld |
| title |
3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione |
| title_short |
3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione |
| title_full |
3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione |
| title_fullStr |
3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione |
| title_full_unstemmed |
3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione |
| title_sort |
3-chloro-4-(5-methoxy-1h-indol-3-yl)cyclobut-3-ene-1,2-dione |
| publisher |
MDPI AG |
| series |
Molbank |
| issn |
1422-8599 |
| publishDate |
2013-07-01 |
| description |
The indole ring system is a prominent partial structure of several protein kinase inhibitor families. The title compound is the first example of a 5-substituted indolyl squaryl chloride with free indole nitrogen. It has been synthesized by reaction of 5-methoxyindole with squaric acid dichloride in diethyl ether and its IR, 1H-NMR, 13C-NMR, MS, UV and HPLC data are presented. This compound may prove to be a rather useful building block for the preparation of various derivatives for biological studies. |
| topic |
Friedel-Crafts acylation indole squaric acid dichloride |
| url |
http://www.mdpi.com/1422-8599/2013/3/M805 |
| work_keys_str_mv |
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