Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study

Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3+ regulatory T cells. Interestingly, MMP9, which was reported as one of the functional m...

Full description

Bibliographic Details
Main Authors: Sadanori Furudate, Taku Fujimura, Gen-ichi Tojo, Takahiro Haga, Setsuya Aiba
Format: Article
Language:English
Published: Karger Publishers 2013-03-01
Series:Case Reports in Dermatology
Subjects:
Xeroderma pigmentosum
Basal cell carcinoma
CD163+
M2 macrophages
Foxp3
Online Access:http://www.karger.com/Article/FullText/350182
id doaj-d36ff9562dd047d3abecd9c60d0b3916
record_format Article
spelling doaj-d36ff9562dd047d3abecd9c60d0b39162020-11-25T00:25:38ZengKarger PublishersCase Reports in Dermatology1662-65672013-03-0151646810.1159/000350182350182Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical StudySadanori FurudateTaku FujimuraGen-ichi TojoTakahiro HagaSetsuya AibaWe describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3+ regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was al-so detected in the CD163+ M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.http://www.karger.com/Article/FullText/350182Xeroderma pigmentosumBasal cell carcinomaCD163+M2 macrophagesFoxp3
collection DOAJ
language English
format Article
sources DOAJ
author Sadanori Furudate
Taku Fujimura
Gen-ichi Tojo
Takahiro Haga
Setsuya Aiba
spellingShingle Sadanori Furudate
Taku Fujimura
Gen-ichi Tojo
Takahiro Haga
Setsuya Aiba
Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
Case Reports in Dermatology
Xeroderma pigmentosum
Basal cell carcinoma
CD163+
M2 macrophages
Foxp3
author_facet Sadanori Furudate
Taku Fujimura
Gen-ichi Tojo
Takahiro Haga
Setsuya Aiba
author_sort Sadanori Furudate
title Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_short Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_full Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_fullStr Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_full_unstemmed Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_sort basal cell carcinoma arising from xeroderma pigmentosum: a case report and an immunohistochemical study
publisher Karger Publishers
series Case Reports in Dermatology
issn 1662-6567
publishDate 2013-03-01
description We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3+ regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was al-so detected in the CD163+ M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.
topic Xeroderma pigmentosum
Basal cell carcinoma
CD163+
M2 macrophages
Foxp3
url http://www.karger.com/Article/FullText/350182
work_keys_str_mv AT sadanorifurudate basalcellcarcinomaarisingfromxerodermapigmentosumacasereportandanimmunohistochemicalstudy
AT takufujimura basalcellcarcinomaarisingfromxerodermapigmentosumacasereportandanimmunohistochemicalstudy
AT genichitojo basalcellcarcinomaarisingfromxerodermapigmentosumacasereportandanimmunohistochemicalstudy
AT takahirohaga basalcellcarcinomaarisingfromxerodermapigmentosumacasereportandanimmunohistochemicalstudy
AT setsuyaaiba basalcellcarcinomaarisingfromxerodermapigmentosumacasereportandanimmunohistochemicalstudy
_version_ 1725347839043698688

Similar Items