Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study

Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3+ regulatory T cells. Interestingly, MMP9, which was reported as one of the functional m...

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Bibliographic Details
Main Authors: Sadanori Furudate, Taku Fujimura, Gen-ichi Tojo, Takahiro Haga, Setsuya Aiba
Format: Article
Language:English
Published: Karger Publishers 2013-03-01
Series:Case Reports in Dermatology
Subjects:
Xeroderma pigmentosum
Basal cell carcinoma
CD163+
M2 macrophages
Foxp3
Online Access:http://www.karger.com/Article/FullText/350182
Description
Summary:We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3+ regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was al-so detected in the CD163+ M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.
ISSN:1662-6567

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