An Activatable T<sub>1</sub>-Weighted MR Contrast Agent: A Noninvasive Tool for Tracking the Vicinal Thiol Motif of Thioredoxin in Live Cells

An Activatable T<sub>1</sub>-Weighted MR Contrast Agent: A Noninvasive Tool for Tracking the Vicinal Thiol Motif of Thioredoxin in Live Cells

We have synthesized new magnetic resonance imaging (MRI) T<sub>1</sub> contrast agents (CA1 and CA2) that permit the activatable recognition of the cellular vicinal thiol motifs of the protein thioredoxin. The contrast agents showed MR relaxivities typical of gadolinium complexes with a...

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Bibliographic Details
Main Authors: Jongeun Kang, Eunha Hwang, Hyunseung Lee, Mi Young Cho, Sanu Karan, Hak Nam Kim, Jong Seung Kim, Jonathan L. Sessler, Sankarprasad Bhuniya, Kwan Soo Hong
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
MR relaxivity
activatable contrast
thioredoxin
vicinal thiols
Online Access:https://www.mdpi.com/1420-3049/26/7/2018

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https://www.mdpi.com/1420-3049/26/7/2018

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