Total Flavonoids from Mimosa Pudica Protects Carbon Tetrachloride -Induced Acute Liver Injury in Mice

• Main Authors: Zhen-qin QIU, Lei CAI, Da-shuai CHEN
• Format: Article
• Language: English
• Published: Third Party Medicine International Publishing Group Co. Limited 2015-03-01
• Series: Journal of International Translational Medicine
• Subjects: Total flavones; Mimosa Pudica; CCl4; Acute liver damage; Mice; Protective effect
• Online Access: http://www.jitm.hk/EN/abstract/abstract128.shtml
• ISSN: 2227-6394

Objective: To observe the protective effect of total flavonoids from Mimosa pudica on carbon tetrachloride (CCl4)-induced acute liver injury in mice. Methods: CCl4-induced acute liver injury model in mice was established. The activity of ALT and AST, the content of serum albumin (Alb) and total antioxidant capacity (T-AOC) were determined. The content of malondiadehyde (MDA) was measured and the activity of superoxide dismutase (SOD) was determined. The histopathological changes of liver were observed.Results: Compared with CCl4 modle group, each dose group of total flavonouida from Mimosa pudica couldreduced the activity of ALT and AST in mice obviously (P＜0.01), indicating they had remarkably protective effect on CCl4-induced acute liver injury in mice. high and middle dose groups of total flavonouida from Mimosa pudica couldincrease the content of Alb in mice (P＜0.01). Each dose group of total flavonouida from Mimosa pudica could enhance the level of T-AOC (P＜0.01). each dose group of total flavonouida from Mimosa pudica could lower the content of liver homogenate MDA but enhance the activity of SOD in a dose-depended manner (P＜0.01). Conclusion: Total flavones from Mimosa Pudica have obvious protective effect on CCl4-induced acute liver injury in mice.