CD11b Activity Modulates Pathogenesis of Lupus Nephritis

CD11b Activity Modulates Pathogenesis of Lupus Nephritis

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) with unclear etiology and limited treatment options. Immune cell infiltration into the kidneys, a hallmark of LN, triggers tissue damage and proteinuria. CD11b, the α-chain of integrin receptor CD11b/CD18 (also known...

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Bibliographic Details
Main Authors: Samia Q. Khan, Imran Khan, Vineet Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Medicine
Subjects:
lupus nephritis
CD11b
ITGAM
type I interferon
leukadherin-1
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00052/full

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