Synthesis and characterization of novel imidazoquinoline based 2-azetidinones as potent antimicrobial and anticancer agents

Synthesis and characterization of novel imidazoquinoline based 2-azetidinones as potent antimicrobial and anticancer agents

A new series of N-substituted azetidinones (9a–h) synthesized by condensation of 4-arylidene hydrazino 1-isobutyl-1H-imidazo[4,5-c]quinolines (8a–h) with chloroacetyl chloride afforded 4-arylazetidin-2-ones (9a–h). The synthesized compounds were characterized by 1H NMR, 13C NMR, mass spectral and el...

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Bibliographic Details
Main Authors: Reshma Kayarmar, G.K. Nagaraja, Prashantha Naik, H. Manjunatha, B.C. Revanasiddappa, T. Arulmoli
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Saudi Chemical Society
Subjects:
Imidazoquinoline
Hydrazone
Azetidinone
Antimicrobial activity
Anticancer activity
β-Tubulin
Docking study
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610314001264

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http://www.sciencedirect.com/science/article/pii/S1319610314001264

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