Research progress on damage ⁃ associated molecular patterns in intracerebral hemorrhage

• Main Authors: YU Zhi⁃yuan, ZHENG Jun, MA Lu, LI Hao, YOU Chao
• Format: Article
• Language: English
• Published: Tianjin Huanhu Hospital 2021-02-01
• Series: Chinese Journal of Contemporary Neurology and Neurosurgery
• Subjects: cerebral hemorrhage; brain injuries; heme; hmgb1 protein; s100 proteins; peroxiredoxins; review
• Online Access: http://www.cjcnn.org/index.php/cjcnn/article/view/2277

After the onset of intracerebral hemorrhage (ICH), the immune storm causes the massive death of neurons and their supporting cells. Cytotoxic substances such as hemoglobin, heme and iron ions released by red blood cells lysis also promote death of neurons. After neurons died, damage⁃associated molecular patterns (DAMP) are released to activate the innate immune response, leading to a vicious circle of "inflammatory response⁃cell death⁃DAMP release⁃inflammatory response", which is an important mechanism of secondary brain injury after ICH. A series of studies have explored the role of DAMP in secondary brain injury after ICH. This review summarizes the research progress and provides references for further basic research and clinical translational research. doi：10.3969/j.issn.1672⁃6731.2021.02.004