Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains.

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains.

Orthomyxovirus Influenza A virus (IAV) heterotrimeric polymerase performs transcription of viral mRNAs by cap-snatching, which involves generation of capped primers by host pre-mRNA binding via the PB2 subunit cap-binding site and cleavage 10-13 nucleotides from the 5' cap by the PA subunit end...

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Bibliographic Details
Main Authors: Delphine Guilligay, Jan Kadlec, Thibaut Crépin, Thomas Lunardi, Denis Bouvier, Georg Kochs, Rob W H Ruigrok, Stephen Cusack
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3893164?pdf=render

Internet

http://europepmc.org/articles/PMC3893164?pdf=render

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