Structural determinants and regulation of spontaneous activity in GABAA receptors

Structural determinants and regulation of spontaneous activity in GABAA receptors

GABAA receptors (GABAARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibit...

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Main Authors: Craig A. Sexton, Reka Penzinger, Martin Mortensen, Damian P. Bright, Trevor G. Smart
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25633-0
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spelling doaj-d345dc169b86449ab9fb68e8dd692c862021-09-19T11:48:32ZengNature Publishing GroupNature Communications2041-17232021-09-0112111810.1038/s41467-021-25633-0Structural determinants and regulation of spontaneous activity in GABAA receptorsCraig A. Sexton0Reka Penzinger1Martin Mortensen2Damian P. Bright3Trevor G. Smart4Department of Neuroscience, Physiology & Pharmacology, UCLDepartment of Neuroscience, Physiology & Pharmacology, UCLDepartment of Neuroscience, Physiology & Pharmacology, UCLDepartment of Neuroscience, Physiology & Pharmacology, UCLDepartment of Neuroscience, Physiology & Pharmacology, UCLGABAA receptors (GABAARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibition.https://doi.org/10.1038/s41467-021-25633-0
collection DOAJ
language English
format Article
sources DOAJ
author Craig A. Sexton
Reka Penzinger
Martin Mortensen
Damian P. Bright
Trevor G. Smart
spellingShingle Craig A. Sexton
Reka Penzinger
Martin Mortensen
Damian P. Bright
Trevor G. Smart
Structural determinants and regulation of spontaneous activity in GABAA receptors
Nature Communications
author_facet Craig A. Sexton
Reka Penzinger
Martin Mortensen
Damian P. Bright
Trevor G. Smart
author_sort Craig A. Sexton
title Structural determinants and regulation of spontaneous activity in GABAA receptors
title_short Structural determinants and regulation of spontaneous activity in GABAA receptors
title_full Structural determinants and regulation of spontaneous activity in GABAA receptors
title_fullStr Structural determinants and regulation of spontaneous activity in GABAA receptors
title_full_unstemmed Structural determinants and regulation of spontaneous activity in GABAA receptors
title_sort structural determinants and regulation of spontaneous activity in gabaa receptors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description GABAA receptors (GABAARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibition.
url https://doi.org/10.1038/s41467-021-25633-0
work_keys_str_mv AT craigasexton structuraldeterminantsandregulationofspontaneousactivityingabaareceptors
AT rekapenzinger structuraldeterminantsandregulationofspontaneousactivityingabaareceptors
AT martinmortensen structuraldeterminantsandregulationofspontaneousactivityingabaareceptors
AT damianpbright structuraldeterminantsandregulationofspontaneousactivityingabaareceptors
AT trevorgsmart structuraldeterminantsandregulationofspontaneousactivityingabaareceptors
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