AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

• Main Authors: Lagarde Michel, Hachem Mayssa, Picq Madeleine, Guichardant Michel, Bernoud-Hubac Nathalie
• Format: Article
• Language: English
• Published: EDP Sciences 2016-01-01
• Series: Oilseeds and fats, crops and lipids
• Subjects: AceDoPC®; acetyl-LysoPC-DHA; blood-brain barrier; carrier
• Online Access: http://dx.doi.org/10.1051/ocl/2015061

AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC® a promising phospholipid carrier of DHA to the brain.