BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives oste...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-020-01606-9 |
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doaj-d333b9fe3c4e40e28331a8e504c5dc912021-01-24T12:24:44ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111410.1038/s42003-020-01606-9BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathwaysYingnan Geng0Huichuan Duan1Liang Xu2Nevin Witman3Bingqian Yan4Zheyuan Yu5Huijing Wang6Yao Tan7Liqin Lin8Dong Li9Shanshan Bai10Regina Fritsche-Danielson11Jie Yuan12Kenneth Chien13Min Wei14Wei Fu15Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Medicine, Karolinska InstitutetInstitute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityResearch and Early Clinical Development, Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZenecaDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Medicine, Karolinska InstitutetDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityGeng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects.https://doi.org/10.1038/s42003-020-01606-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yingnan Geng Huichuan Duan Liang Xu Nevin Witman Bingqian Yan Zheyuan Yu Huijing Wang Yao Tan Liqin Lin Dong Li Shanshan Bai Regina Fritsche-Danielson Jie Yuan Kenneth Chien Min Wei Wei Fu |
| spellingShingle |
Yingnan Geng Huichuan Duan Liang Xu Nevin Witman Bingqian Yan Zheyuan Yu Huijing Wang Yao Tan Liqin Lin Dong Li Shanshan Bai Regina Fritsche-Danielson Jie Yuan Kenneth Chien Min Wei Wei Fu BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways Communications Biology |
| author_facet |
Yingnan Geng Huichuan Duan Liang Xu Nevin Witman Bingqian Yan Zheyuan Yu Huijing Wang Yao Tan Liqin Lin Dong Li Shanshan Bai Regina Fritsche-Danielson Jie Yuan Kenneth Chien Min Wei Wei Fu |
| author_sort |
Yingnan Geng |
| title |
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways |
| title_short |
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways |
| title_full |
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways |
| title_fullStr |
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways |
| title_full_unstemmed |
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways |
| title_sort |
bmp-2 and vegf-a modrnas in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-01-01 |
| description |
Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects. |
| url |
https://doi.org/10.1038/s42003-020-01606-9 |
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