Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine
The reaction of nitrilimine 6a with ethyl pyridine-2-acetate (7) gave thecorresponding pyrrolo[1,2-a]pyridine 8, while the reaction of 6b containing an estermoiety afforded the acyclic adduct 9. The reaction of 6a with 2-aminopyrimidine (10)gave the novel unexpected pyrimido[2,1-d]1,2,3,5-tetrazine...
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MDPI AG
2008-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/13/1/170/ |
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doaj-d332e47be9ff4f7b8e367e7c5b6995322020-11-24T23:32:58ZengMDPI AGMolecules1420-30492008-01-0113117017610.3390/molecules13010170Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazineJalal A. ZahraAdel M. AwadallahThe reaction of nitrilimine 6a with ethyl pyridine-2-acetate (7) gave thecorresponding pyrrolo[1,2-a]pyridine 8, while the reaction of 6b containing an estermoiety afforded the acyclic adduct 9. The reaction of 6a with 2-aminopyrimidine (10)gave the novel unexpected pyrimido[2,1-d]1,2,3,5-tetrazine 11. Acyclic adducts 16 and17 were obtained from the reaction of 6b with 2-cyanomethylbenzimidazole (14) and 2-aminobenzimidazole (15), respectively.http://www.mdpi.com/1420-3049/13/1/170/Nitriliminesethyl pyridine-2-acetatepyrrolo[12-a]pyridine2-aminopyrimidine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jalal A. Zahra Adel M. Awadallah |
| spellingShingle |
Jalal A. Zahra Adel M. Awadallah Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine Molecules Nitrilimines ethyl pyridine-2-acetate pyrrolo[1 2-a]pyridine 2-aminopyrimidine |
| author_facet |
Jalal A. Zahra Adel M. Awadallah |
| author_sort |
Jalal A. Zahra |
| title |
Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine |
| title_short |
Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine |
| title_full |
Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine |
| title_fullStr |
Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine |
| title_full_unstemmed |
Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine |
| title_sort |
reaction of nitrilimines with 2-substituted aza-heterocycles. synthesis of pyrrolo[1,2-a]pyridine and pyrimido[2,1-d]1,2,3,5- tetrazine |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2008-01-01 |
| description |
The reaction of nitrilimine 6a with ethyl pyridine-2-acetate (7) gave thecorresponding pyrrolo[1,2-a]pyridine 8, while the reaction of 6b containing an estermoiety afforded the acyclic adduct 9. The reaction of 6a with 2-aminopyrimidine (10)gave the novel unexpected pyrimido[2,1-d]1,2,3,5-tetrazine 11. Acyclic adducts 16 and17 were obtained from the reaction of 6b with 2-cyanomethylbenzimidazole (14) and 2-aminobenzimidazole (15), respectively. |
| topic |
Nitrilimines ethyl pyridine-2-acetate pyrrolo[1 2-a]pyridine 2-aminopyrimidine |
| url |
http://www.mdpi.com/1420-3049/13/1/170/ |
| work_keys_str_mv |
AT jalalazahra reactionofnitrilimineswith2substitutedazaheterocyclessynthesisofpyrrolo12apyridineandpyrimido21d1235tetrazine AT adelmawadallah reactionofnitrilimineswith2substitutedazaheterocyclessynthesisofpyrrolo12apyridineandpyrimido21d1235tetrazine |
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