Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration

Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration

Abstract Introduction To examine whether sex and polymorphisms of cytochrome P450 (CYP) 2B6 and UDP-glucuronosyltransferase (UGT) 1A9 affect the difference between predicted and measured plasma propofol concentration during continuous infusion by target-controlled infusion. Results Blood samples of...

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Bibliographic Details
Main Authors: Ai Fujita, Kengo Hayamizu, Tatsuya Yoshihara, Masayoshi Zaitsu, Fumie Shiraishi, Hisatomi Arima, Kazumasa Matsuo, Kanako Shiokawa, Hidekazu Setoguchi, Toshiyuki Sasaguri
Format: Article
Language:English
Published: SpringerOpen 2018-08-01
Series:JA Clinical Reports
Subjects:
Propofol
Target-controlled infusion
Polymorphism
Sex difference
Mean blood pressure
Heart rate
Online Access:http://link.springer.com/article/10.1186/s40981-018-0196-8

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