A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice

A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice

Abstract Background While the genetics of obesity has been well defined, the epigenetics of obesity is poorly understood. Here, we used a genome-wide approach to identify genes with differences in both DNA methylation and expression associated with a high-fat diet in mice. Results We weaned genetica...

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Bibliographic Details
Main Authors: Madeline Rose Keleher, Rabab Zaidi, Lauren Hicks, Shyam Shah, Xiaoyun Xing, Daofeng Li, Ting Wang, James M. Cheverud
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Genomics
Subjects:
Obesity
Mice
Epigenetics
Methylation
RNA-seq
Gene expression
Online Access:http://link.springer.com/article/10.1186/s12864-018-5327-0

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