Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans

Alteration of the lipid composition of biological membranes interferes with their function and can cause tissue damage by triggering apoptosis. Upon lipid bilayer stress, the endoplasmic reticulum mounts a stress response similar to the unfolded protein response. However, only a few genes are known...

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Bibliographic Details
Main Authors: Richard Venz, Anastasiia Korosteleva, Elisabeth Jongsma, Collin Y. Ewald
Format: Article
Language:English
Published: Oxford University Press 2020-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
lipid bilayer stress
lipotoxicity
unfolded protein stress
auxin-induced degradation
creb3
nrf2
mdt-15
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401635

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