Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis

Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis

Abstract Background Intestinal barrier dysfunction is a significant clinical problem, commonly developing in a variety of acute or chronic pathological conditions. Herein, we evaluate the effect of microRNA-31 (miR-31) on intestinal barrier dysfunction through NF-κB/HIF-1α pathway by targeting HMOX1...

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Bibliographic Details
Main Authors: Cheng-Ye Zhan, Di Chen, Jin-Long Luo, Ying-Hua Shi, You-Ping Zhang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Medicine
Subjects:
microRNA-31
Sepsis
HMOX1
NF-κB/HIF-1α pathway
Intestinal barrier dysfunction
Online Access:http://link.springer.com/article/10.1186/s10020-018-0053-2

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