New Peptide-Based Pharmacophore Activates 20S Proteasome

New Peptide-Based Pharmacophore Activates 20S Proteasome

The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood cancers. However, the clinical potential of proteas...

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Bibliographic Details
Main Authors: Paweł A. Osmulski, Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczyńska
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
proteasome
activation
allostery
peptides
beta turn
proteasome dynamics
atomic force microscopy
Online Access:https://www.mdpi.com/1420-3049/25/6/1439

Internet

https://www.mdpi.com/1420-3049/25/6/1439

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